For individuals having certain types of blood cancer such as multiple myeloma and non-Hodgkin lymphoma, stem cell transplantation might be a very useful method. Before an autologous stem cell transplant, it is necessary for physicians to extract a sufficient quantity of blood-forming stem cells from the blood of an individual because stem cells are normally found in the bone marrow. In order to make stem cells leave bone marrow, certain therapies might be used such as Plerixafor Injection that works in conjunction with filgrastim.
What Is Plerixafor Injection?
It is a medication that promotes mobilization of hematopoietic stem cells from bone marrow to the blood. This medication is not directly killing cancer cells as in the case of chemotherapy, however its primary role is assisting in the stem cell harvesting process. It is given along with filgrastim in selected cases of multiple myeloma and non-Hodgkin lymphoma.
How Does The Medicine Work In The Body?
The Injection functions by inhibiting the activity of the CXCR4 receptor and preventing its binding to the CXCL12 (SDF-1) ligand. As a result, hematopoietic stem cells are released from the bone marrow and enter the circulation where they can be harvested using apheresis.
When Is The Injection Used?
It is administered to specific patients suffering from either multiple myeloma or non-Hodgkin lymphoma who are eligible for stem cell collection and transplantation. Also, the medicine is normally given in combination with other drugs including growth factors, for instance, filgrastim.
How to Administered The Medicine?
The medicine is given as a subcutaneous injection, which is injected under the skin. It is typically taken about 11 hours before the apheresis processed. The dosage is based on body weight, but some people suffering from specific degrees of kidney dysfunction may need dose adjustments. However, the correct time of administration is decided by the transplant team.
What Adverse Reactions Are Caused By The Medicine?
Side effects may occur while using Plerixafor; however, not everyone suffers from these side effects. Some common symptoms may include the following:
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Diarrhea
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Nausea
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Fatigue
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Headache
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Dizziness
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Vomiting
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Joint pain
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Injection site reactions
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Abdominal pain
In case these symptoms get worse, patient should inform the healthcare team promptly.
What Precautions Are Important During The Treatment?
It is important for patients to give their healthcare professionals complete details regarding their medical history and medications. Key factors that should be considered are:
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Issues with kidney
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History of any allergic reaction to medications
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Medications prescribed and non-prescribed
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Intention to conceive or pregnancy
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Unusual shoulder and abdominal pain
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Any history of blood disorders
Conclusion
The injection is used as an adjunct in the mobilization of stem cells in certain individuals suffering from multiple myeloma and non-Hodgkin lymphoma before autologous stem cell transplantation. It works by blocking CXCR4 to facilitate the release of stem cells from the bone marrow into the blood stream where they can then be collected via apheresis. Since its use is very particular to the regimen, Plerixafor injection uses in stem cell mobilization should only be given under the guidance of an oncologist or a transplant specialist.
FAQs
1. What is plerixafor injection Price?
The cost depends on the manufacturer, source, dosage form, quantity, availability, and place. The patients can inquire about the current cost from Globans Pharma, a trusted online licensed pharmacy.
2. Can medicine be taken without doctor's guidance?
No, it needs to be taken in an appropriate dose and with correct timing under the medical supervision of the process.
